The Isabella Lab
How is neuronal connectivity patterned during development and regeneration?
How is neuronal connectivity patterned during development and regeneration?
Welcome to the Isabella Lab at the University of Minnesota. Using zebrafish branched nerves as a model, we employ genetic, genomic, embryological and live imaging approaches to understand how single-cell decision-making is regulated and coordinated to generate large-scale patterns of innervation in the nervous system. We take a dual approach to examine how axon target selection is controlled to 1) build patterned branched nerve structures during embryonic development, and 2) rebuild and repattern these structures during regeneration.